Publications


  1. Hoffmann E. Dittrich-Breiholz O. Holtmann H. Kracht M. Multiple control of interleukin-8 gene expression. J Leukoc Biol 72(5):847-855 (2002) Pubmed Citation
  2. Dittrich-Breiholz O. Schneider H. Wehmeier L. Resch K. Kracht M. Entwicklung und Evaluierung eines DNA Mikro Arrays für entzündungsrelevante Gene. Biospektrum 1/03:88-92 (2003) Full text (pdf)
  3. Wehmeier L. Dittrich-Breiholz O. Kracht M. Biochips in klinischen Applikationen: Ermittlung von Genexpressionsprofilen im Entzündungsprozess. Managment und Krankenhaus (2003)
  4. Holzberg D. Knight C.G. Dittrich-Breiholz O. Schneider H. Dörrie A. Hoffmann E. Resch K. Kracht M. Disruption of the c-JUN-JNK complex by a cell-permeable peptide containing the c-JUN delta domain induces apoptosis and affects a distinct set of IL-1-induced inflammatory genes. J.Biol.Chem. 278(41):40213-23 (2003) Abstract/Pubmed Citation
  5. Mattioli I. Dittrich-Breiholz O. Livingstone M. Kracht M. Schmitz M.L. Comparative analysis of T-cell costimulation and CD43 activation reveals novel signaling pathways and target genes. Blood 104(10):3302-4 (2004) Abstract/Pubmed Citation
  6. Kreuz S. Siegmund D. Rumpf J. Samel D. Leverkus M. Janssen O. Hacker G. Dittrich-Breiholz O. Kracht M. Scheurich P. Wajant H. NFκB activation by Fas is mediated through FADD Caspase-8 and RIP and is inhibited by FLIP. J.Cell.Biol. 166(3):369-80 (2004) Abstract/Pubmed Citation
  7. Breuer K. Wittmann M. Kempe K. Kapp A. Mai U. Dittrich-Breiholz O. Kracht M. Mrabet-Dahbi S. Werfel T. Alpha-toxin is produced by skin colonizing Staphylococcus aureus and induces a T helper type 1 response in atopic dermatitis. Clin Exp Allergy 35(8):1088-95 (2005) Pubmed Citation
  8. Hoffmann E. Thiefes A. Buhrow D. Dittrich-Breiholz O. Schneider H. Resch K. Kracht M. MEK1-dependent delayed expression of FRA-1 counteracts c-FOS and p65 NF-κB mediated Interleukin-8 transcription in response to cytokines or growth factors. J.Biol.Chem. 280(10):9706-18 (2005) Abstract/Pubmed Citation
  9. Thiefes A. Wolter S. Mushinski J. F. Hoffmann E. Dittrich-Breiholz O. Graue N. Dörrie A. Schneider H. Wirth D. Luckow B. Resch K. Kracht M. Simultaneous blockade of NFκB JNK and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of TNF target genes J.Biol.Chem.Abstract/Pubmed Citation
  10. Siegmund D. Wicovsky A. Schmitz I. Schulze-Osthoff K. Kreuz S. Leverkus M. Dittrich-Breiholz O. Kracht M. Wajant H. Death receptor-induced signaling pathways are differentiallyregulated by interferon-γ upstream of caspase-8 processing. Mol.Cell.Biol. 25(15):6363-79 (2005) Online Version/Pubmed Citation
  11. Breuer K. Wittmann M. Kempe K. Kapp A. Mai U. Dittrich-Breiholz O. Kracht M. Mrabet-Dahb S. Werfel T. Alpha-toxin is produced by skin colonizing Staphylococcus aureus and induces a TH1 response in atopic dermatitis. Clin.Exp.Allergy 35(8):1088-95 (2005) Abstract/Pubmed Citation
  12. Kracht M. Holtmann H. Cytokines. Invited contribution to Ganten D. Ruckpaul K. (Eds.): „Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine“ Springer Verlag ISBN: 978-3-540-29623-2 (2006)
  13. Schroder N. Sekhar A. Geffers I. Muller J. Dittrich-Breiholz O. Kracht M. Wedemeyer J. Gossler A. Identification of mouse genes with highly specific expression patterns in differentiated intestinal epithelium. Gastroenterology 130(3):902-7 (2006) Online Version/Pubmed Citation
  14. Gowrishankar G. Winzen R. Dittrich-Breiholz O. Redich N. Kracht M. Holtmann H. Inhibition of mRNA deadenylation and degradation by different types of cell stress. Biol.Chem. 387(3):323-7 (2006) Abstract/Pubmed Citation
  15. Kettner-Buhrow D. Dittrich-Breiholz O. Schneider H. Wolter S. Resch K. Kracht M. Small interfering RNAs generated by recombinant dicer induce inflammatory gene expression independent from the TAK1-NFκB-MAPK signaling pathways. Biochem.Biophys.Res.Commun. 347(3):566-73 (2006) Online Version/Pubmed Citation
  16. Purwar R. Wittmann M. Zwirner J. Oppermann M. Kracht M. Dittrich-Breiholz O. Gutzmer R. Werfel T. Induction of C3 and CCL2 by C3a in keratinocytes: a novel autocrine amplification loop of inflammatory skin reactions. J.Immunol. 177(7):4444-50 (2006) Online Version/Pubmed Citation
  17. Spender L.C. Lucchesi W. Bodelon G. Bilancio A. Karstegl C.E. Asano T. Dittrich-Breiholz O. Kracht M. Vanhaesebroeck B. Farrell P.J. Cell target genes of Epstein-Barr virus transcription factor EBNA-2: induction of the p55alpha regulatory subunit of PI3-kinase and its role in survival of EREB2.5 cells. J.Gen.Virol. 87(Pt 10):2859-67 (2006) Online Version/Pubmed Citation
  18. Ansari A.W. Bhatnagar N. Dittrich-Breiholz O. Kracht M. Schmidt R.E. Heiken H. Host chemokine (C-C motif) ligand-2 (CCL2) is differentially regulated in HIV type 1 (HIV-1)-infected individuals. Int Immunol 18(10):1443-51 (2006) Online Version/Pubmed Citation
  19. Ronkina N. Kotlyarov A. Dittrich-Breiholz O. Kracht M. Hitti E. Milarski K. Askew R. Marusic S. Lin L.L. Gaestel M. Telliez J.B. The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK. Mol.Cell.Biol. 27(1):170-81 (2007) Online Version/Pubmed Citation
  20. Brinkmann M.M. Pietrek M. Dittrich-Breiholz O. Kracht M. Schulz T.F. Modulation of host gene expression by the K15 protein of Kaposi's sarcoma-associated herpesvirus. J.Virol. 81(1):42-58 (2007) Online Version/Pubmed Citation
  21. Wang L. Brinkmann M.M. Pietrek M. Ottinger M. Dittrich-Breiholz O. Kracht M. Schulz T.F. Functional characterization of the M-type K15-encoded membrane protein of Kaposi's sarcoma-associated herpesvirus. J.Gen.Virol. 88(Pt 6):1698-707 (2007) Online Version/Pubmed Citation
  22. Winzen R. Thakur B.K. Dittrich-Breiholz O. Shah M. Redich N. Dhamija S. Kracht M. Holtmann H. Functional analysis of KSRP interaction with the AU-rich element of interleukin-8 and identification of inflammatory mRNA targets. Mol Cell Biol 27(23):8388-8400 (2007) Pubmed Citation
  23. del Rio M.L. Rodriguez-Barbosa J.I. Bolter J. Ballmaier M. Dittrich-Breiholz O. Kracht M. Jung S. Forster R. CX3CR1+ c-kit+ bone marrow cells give rise to CD103+ and C. J Immunol 181(9):6178-88 (2008) Pubmed Citation
  24. Hoffmann E. Ashouri J. Wolter S. Doerrie A. Dittrich-Breiholz O. Schneider H. Wagner E.F. Troppmair J. Mackman N. Kracht M. Transcriptional regulation of EGR-1 by the interleukin-1-JNK-MKK7-c-Jun pathway. J Biol Chem 283(18):12120-28 (2008) Pubmed Citation
  25. Lucchesi W. Brady G. Dittrich-Breiholz O. Kracht M. Russ R. Farrell P.J. Differential gene regulation by Epstein-Barr virus type 1 and type 2 EBNA2. J Virol 82(15):7456-66 (2008) Pubmed Citation
  26. Wolter S. Doerrie A. Weber A. Schneider H. Hoffmann E. von der O.J. Bakiri L. Wagner E.F. Resch K. Kracht M. c-Jun controls histone modifications, NF-kappaB recruitment, and RNA polymerase II function to activate the ccl2 gene. Mol Cell Biol 28(13):4407-4423 (2008) Pubmed Citation
  27. Berg D. Stuhmer T. Siegmund D. Muller N. Giner T. Dittrich-Breiholz O. Kracht M. Bargou R. Wajant H. Oligomerized tumor necrosis factor-related apoptosis inducing ligand strongly induces cell death in myeloma cells, but also activates proinflammatory signaling pathways. FEBS J 276(23):6912-27 (2009) Pubmed Citation
  28. Geng H. Wittwer T. Dittrich-Breiholz O. Kracht M. Schmitz M.L. Phosphorylation of NF-kappaB p65 at Ser468 controls its COMMD1-dependent ubiquitination and target gene-specific proteasomal elimination. EMBO Rep 10(4):381-86 (2009) Pubmed Citation
  29. Johswich K. Martin M. Bleich A. Kracht M. Dittrich-Breiholz O. Gessner J.E. Suerbaum S. Wende E. Rheinheimer C. Klos A. Role of the C5a receptor (C5aR) in acute and chronic dextran sulfate-induced models of inflammatory bowel disease. Inflamm Bowel Dis 15(12):1812-23 (2009) Pubmed Citation
  30. Kovalenko A. Kim J.C. Kang T.B. Rajput A. Bogdanov K. Dittrich-Breiholz O. Kracht M. Brenner O. Wallach D. Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease. J Exp Med 206(10):2161-77 (2009) Pubmed Citation
  31. Mosa A. Trumstedt C. Eriksson E. Soehnlein O. Heuts F. Janik K. Klos A. Dittrich-Breiholz O. Kracht M. Hidmark A. Wigzell H. Rottenberg M.E. Nonhematopoietic cells control the outcome of infection with Listeria monocytogenes in a nucleotide oligomerization domain 1-dependent manner. Infect Immun 77(7):2908-2918 (2009) Pubmed Citation
  32. Wang L. Pietrek M. Brinkmann M.M. Havemeier A. Fischer I. Hillenbrand B. Dittrich-Breiholz O. Kracht M. Chanas S. Blackbourn D.J. Schulz T.F. Identification and functional characterization of a spliced rhesus rhadinovirus gene with homology to the K15 gene of Kaposi's sarcoma-associated herpesvirus. J Gen Virol 90(Pt 5):1190-1201 (2009) Pubmed Citation
  33. Dhamija S. Doerrie A. Winzen R. Dittrich-Breiholz O. Taghipour A. Kuehne N. Kracht M. Holtmann H. IL-1-induced post-transcriptional mechanisms target overlapping translational silencing and destabilizing elements in IkappaBzeta mRNA. J Biol Chem 285(38):29165-78 (2010) Pubmed Citation
  34. Ehrenschwender M. Siegmund D. Wicovsky A. Kracht M. Dittrich-Breiholz O. Spindler V. Waschke J. Kalthoff H. Trauzold A. Wajant H. Mutant PIK3CA licenses TRAIL and CD95L to induce non-apoptotic caspase-8-mediated ROCK activation. Cell Death Differ 17(9):1435-47 (2010) Pubmed Citation
  35. Pietrek M. Brinkmann M.M. Glowacka I. Enlund A. Havemeier A. Dittrich-Breiholz O. Kracht M. Lewitzky M. Saksela K. Feller S.M. Schulz T.F. Role of the Kaposi's sarcoma-associated herpesvirus K15 SH3 binding site in inflammatory signaling and B-cell activation. J Virol 84(16):8231-40 (2010) Pubmed Citation
  36. Alkharsah K.R. Singh V.V. Bosco R. Santag S. Grundhoff A. Konrad A. Sturzl M. Wirth D. Dittrich-Breiholz O. Kracht M. Schulz T.F. Deletion of Kaposi's sarcoma-associated herpesvirus FLICE inhibitory protein, vFLIP, from the viral genome compromises the activation of STAT1-responsive cellular genes and spindle cell formation in endothelial cells. J Virol 85(19):10375-10388 (2011) Pubmed Citation
  37. Dhamija S. Kuehne N. Winzen R. Doerrie A. Dittrich-Breiholz O. Thakur B.K. Kracht M. Holtmann H. Interleukin-1 activates synthesis of interleukin-6 by interfering with a KH-type splicing regulatory protein (KSRP)-dependent translational silencing mechanism. J Biol Chem 286(38):33279-33288 (2011) Pubmed Citation
  38. Dutta P. Koch A. Breyer B. Schneider H. Dittrich-Breiholz O. Kracht M. Tamura T. Identification of novel target genes of nerve growth factor (NGF) in human mastocytoma cell line (HMC-1 (V560G c-Kit)) by transcriptome analysis. BMC Genomics 12196 (2011) Pubmed Citation
  39. Gerhard R. Queisser S. Tatge H. Meyer G. Dittrich-Breiholz O. Kracht M. Feng H. Just I. Down-regulation of interleukin-16 in human mast cells HMC-1 by Clostridium difficile toxins A and B. Naunyn Schmiedebergs Arch Pharmacol 383(3):285-295 (2011) Pubmed Citation
  40. Gregorovic G. Bosshard R. Karstegl C.E. White R.E. Pattle S. Chiang A.K. Dittrich-Breiholz O. Kracht M. Russ R. Farrell P.J. Cellular gene expression that correlates with EBER expression in Epstein-Barr Virus-infected lymphoblastoid cell lines. J Virol 85(7):3535-45 (2011) Pubmed Citation
  41. Kasraie S. Niebuhr M. Kopfnagel V. Dittrich-Breiholz O. Kracht M. Werfel T. Macrophages from patients with atopic dermatitis show a reduced CXCL10 expression in response to staphylococcal alpha-toxin. Allergy 67(1):41-49 (2012) Pubmed Citation
  42. Li H. Wittwer T. Weber A. Schneider H. Moreno R. Maine G.N. Kracht M. Schmitz M.L. Burstein E. Regulation of NF-kappaB activity by competition between RelA acetylation and ubiquitination. Oncogene (2011) Pubmed Citation
  43. Rzeczkowski K. Beuerlein K. Muller H. Dittrich-Breiholz O. Schneider H. Kettner-Buhrow D. Holtmann H. Kracht M. c-Jun N-terminal kinase phosphorylates DCP1a to control formation of P bodies. J Cell Biol 194(4):581-596 (2011) Pubmed Citation